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Liverpool vs Atletico Madrid Predictions: 17.09.2025 - Champions League Betting Tips

Publish Date: 15/09/2025
Fact checked by: Jordan Noble

Liverpool vs Atletico Madrid

Liverpool start their Champions League bid by welcoming Atletico Madrid to Anfield on Wednesday evening. Having won all four of their Premier League matches, Arne Slot's side head into this match as the clear favourites. However, after losing their first La Liga match, Atletico Madrid are now unbeaten in their last three - and Diego Simeone will look to keep that going on the road.

Liverpool's attack is too good

A last gasp penalty strike from Mohammed Salah helped Liverpool keep their 100% win rate up and make it back-to-back clean sheets,

However, what is becoming a noticeable theme is Liverpool winning matches late on. In all four of their wins to date, Liverpool have won the match beyond the 80th minute - and twice in added time.

Slot has addressed two sloppy defensive performances against Bournemouth and Newcastle, but he'll be concerned that his side aren't able to score earlier and make life a little easier for themselves.

Still, Liverpool are winning and scoring - and now they also have Alexander Isak.

Atletico yet to find top gear

It's a big season for Diego Simeone. The Argentine has thrown money at his squad in recent years and before long, fans - and the board - will want to see trophies.

This season didn't start well with a 2-1 defeat against Espanyol. Two draws followed against Elche and Alaves - teams expected to finish in the bottom half. A reset after the international break saw Simeone bag his first victory against Villarreal - which was a step in the right direction.

However, his side head to Anfield a few players short. Jose Gimenez remains a long term absence, but Alex Baena and Thiago Almada will join him in the treatment room - the latter a huge miss having just signed this summer.

Liverpool vs Atletico Madrid H2H

Liverpool and Atletico Madrid have had some intriguing clashes over the years. Atletico Madrid have won two of their last five meetings, drawing one other before losing in extra-time back in 2020. But the last two matches have seen Liverpool come away with the wins, although both were back in 2021 in the old Champions League group stage.

Our Liverpool vs Atletico Madrid betting tip

Liverpool's formidable attack is proving too strong for teams to stop and Atletico Madrid, who have kept just one clean sheet from four matches, may struggle to live with their new, expensive forwards. Nathan Joyes puts forward his best bet.

Liverpool to make it five from five

It hasn't been flawless from Liverpool but it's been close enough from what we have seen already. Relentless and clearly willing to fight until the end, Slot's side appear to have a mental edge over their opponents - as well as the quality to pinch the points.

The fact they've now added Isak to their attack surely has to make it one of - if not - the best in the world, and Atletico Madrid will struggle to cope with Liverpool's front line based on what we have seen this season.

A lack of clean sheets and with fans not happy with the early signs, it could be a long evening for the Spanish club. There's plenty of work still to be done this season to make Atletico competitive, and a trip to Anfield might just magnify those cracks on display.

This isn't the Atletico of old, but this new-look Liverpool side is just incredibly dangerous - and they'll fight until the very end. Back Liverpool -1 Asian Handicap at 9/10 - meaning you'll be refunded if the hosts only win by one goal. Good luck if you're following.

TIP: Liverpool -1 Asian Handicap with BetMGM.

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