
Each chasing very different objectives, defeat would be a huge problem for Leicester City and Arsenal, both of whom suffered domestic cup exits last time out.
Leicester are essentially in a three-horse race for 17th place in the Premier League, and they have a slim chance of topping that mini-table come full-time on Saturday afternoon.
The Foxes have lost eight of their last nine in the league, but their one victory during that run did come against North London opposition at the Tottenham Hotspur Stadium.
Ruud van Nistelrooy was denied what would have been a sweet success at Old Trafford in the FA Cup last Friday, as Manchester United from a goal down to win 2-1, with former Leicester defender Harry Maguire headed in a stoppage-time winner.
For Arsenal, the high of dismantling Manchester City at the beginning of the month has been followed by despair. Gabriel Martinelli suffered a hamstring injury in the defeat by Newcastle in the Carabao Cup semi-final, and even more devastatingly, Kai Havertz will miss the rest of the season after tearing the same muscle in training.
Still, the Gunners remain in the title race and can heap some pressure on leaders Liverpool by reducing the gap at the top to four points on Saturday. The return of Ben White is imminent, but Bukayo Saka won’t be back until after this month.
This will likely be the last time that Jamie Vardy lines up for Leicester against Arsenal, in a fixture that has brought him copious joy over the last decade.
The Foxes forward has breached the Gunners defence 11 times. Since Leicester won the Premier League, every time they have beaten Arsenal or earned a score draw, Vardy has found the net.
That is four victories and one draw that the former Fleetwood Town striker has helped them towards. They are his favourite top-flight opponent, despite the Gunners winning each of the last six meetings.
The King Power Stadium has been a happy hunting ground for Mikel Arteta - much more so than it was for previous boss Unai Emery.
Arsenal’s overall record against Leicester is excellent despite the blip towards the end of the 2010s.
Ethan Nwaneri is one of only three fit forwards for Arsenal, and the best bet is for the teenager to score in this fixture.
Nwaneri has been eased into the first team at the Emirates but with Martinelli and Havertz joining Saka on the sidelines, his role is about to become a lot more crucial.
How he deals with that over the coming months remains to be seen, but against the second-worst defence in the league this weekend, he can ease Gunners fans’ fears over their forward line.
His seven goals in all competitions this term have come at an average of a goal every 101 minutes, and given the lack of attacking options at Arteta’s disposal, a full 90 or close to it may be on the cards for Nwaneri.
Leandro Trossard is expected to play through the middle and was almost chosen as the best bet, but Nwaneri has been more clinical in front of goal as of late and has been priced up at bigger odds.
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